Effects of dexmedetomidine on activation of mast cells around hematoma and neurological impairment in mouse intracerebral hemorrhage / 重庆医学
Chongqing Medicine
; (36): 171-175, 2024.
Article
in Zh
| WPRIM
| ID: wpr-1017459
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WPRO
ABSTRACT
Objective To explore the effect of dexmedetomidine on the neurological function and mast cells activation in the mouse with intracerebral hemorrhage(ICH).Methods The mouse was intraperitoneal-ly injected with dexmedetomidine at 30 min before intracerebral hemorrhage.After the preparation of intrace-rebral hemorrhage model,the neurological function,brain water content,number of mast cells around hemato-ma and expression levels of tryptase,IL-1β,TNF-α were detected.Results Compared with the control group,the neurological function score in the intracerebral hemorrhage group was significantly elevated(P<0.05),the brain water content was significantly increased(P<0.05),the mast cells number was significantly in-creased(P<0.05),and the tryptase,IL-1β and TNF-α expression levels were sinificantly increased(P<0.05);while the neurological function score in the dexmedetomidine group was significantly decreased(P<0.05),the brain water content was significantly decreased(P<0.05),the number of mast cells was signifi-cantly reduced and the tryptase,IL-1β and TNF-α expression levels were significantly decreased(P<0.05).Conclusion Dexmedetomidine could inhibit the activation of mast cells around hematoma and reduce the dam-age of neurological function after mouse intracerebral hemorrhage.
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Language:
Zh
Journal:
Chongqing Medicine
Year:
2024
Type:
Article