Significance of Serum Eosinophil Cationic Protein and High-Sensitivity C-reactive Protein Levels in Patients with Allergic and Non-Allergic Inflammatory Diseases
Laboratory Medicine Online
;
: 20-27, 2012.
Article
in Korean
| WPRIM
| ID: wpr-101764
ABSTRACT
BACKGROUND:
This study was conducted to evaluate the significance of serum eosinophil cationic protein (ECP) and high-sensitivity C-reactive protein (hs-CRP) levels in children with allergic diseases and non-allergic inflammatory diseases, and to assess the relationships between serum ECP levels and inflammatory parameters.METHODS:
In this study, we included 146 children with allergic diseases, 76 children with non-allergic inflammatory diseases, and 25 control subjects. Serum concentrations of ECP, hs-CRP, total IgE, and allergen-specific IgE were measured.RESULTS:
Serum ECP levels (77.5+/-88.2 microg/L) of patients with allergic diseases were significantly higher than those of the patients with non-allergic inflammatory diseases (42.2+/-58.8 microg/L) and control subjects (12.7+/-4.2 microg/L) (P0.05).CONCLUSIONS:
Measurement of serum ECP and hs-CRP concentrations can be helpful in the clinical evaluation and monitoring of patients with allergic diseases. No significant correlation was observed between serum ECP and hs-CRP levels in allergic patients, thereby suggesting that elevated levels of ECP do not necessarily reflect the degree of systemic inflammation in allergic diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
C-Reactive Protein
/
Immunoglobulin E
/
Eosinophil Cationic Protein
/
Eosinophils
/
Inflammation
Type of study:
Diagnostic study
Limits:
Child
/
Humans
Language:
Korean
Journal:
Laboratory Medicine Online
Year:
2012
Type:
Article
Similar
MEDLINE
...
LILACS
LIS