Progress of macrophage polarization in the mechanism of bronchopulmonary dysplasia / 国际儿科学杂志

ABSTRACT

Bronchopulmonary dysplasia(BPD)is a common chronic respiratory disease in preterm infants, especially very preterm infants.The pathogenesis of BPD is complex and involves genetics, preterm birth, oxygen toxicity, prenatal and postnatal infections, and mechanical ventilation lung injury.These endogenous and exogenous stimuli lead to an inflammatory cascade in the body.Recent studies have shown that macrophages regulate the inflammatory response in BPD, participate in lung tissue injury and repair, and phagocytose and remove pathogenic microorganisms and apoptotic cells.Although little is known about the mechanisms by which macrophages regulate BPD, their polarised phenotype can influence the expression of a variety of inflammatory factors and signaling pathways, which may further clarify the pathogenesis of BPD.Therefore, this article reviews the mechanism of macrophage polarisation in BPD, to provide new targets and pathways for clinical treatment.