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Role of TREM2-mediated immunomodulation of microglia in ischemic stroke / 国际脑血管病杂志
Article in Zh | WPRIM | ID: wpr-1017948
Responsible library: WPRO
ABSTRACT
Ischemic stroke is a common neurological disorder that can lead to neuronal death and neurological dysfunction. Microglia is the main immune cells in the central nervous system, involved in post-stroke inflammation and tissue repair. Triggering receptor expressed on myeloid cells 2 (TREM2), a receptor expressed on the surface of microglia, plays a multifaceted role in neuronal survival and nerve repair after ischemic stroke, including promoting the phagocytosis of microglia, inhibiting excessive inflammatory response, maintaining the proliferation and survival of microglia, protecting neurons from damage, and promoting the recovery of nerve function. Therefore, elucidating the immunoregulatory mechanism of TREM2 on microglia after cerebral ischemia is of great significance for exploring new therapeutic directions for ischemic stroke.
Key words
Full text: 1 Index: WPRIM Language: Zh Journal: International Journal of Cerebrovascular Diseases Year: 2023 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: International Journal of Cerebrovascular Diseases Year: 2023 Type: Article