Progress of MCL-1 and its inhibitors in hematologic malignancies / 国际肿瘤学杂志
Journal of International Oncology
; (12): 119-122, 2024.
Article
in Zh
| WPRIM
| ID: wpr-1018185
Responsible library:
WPRO
ABSTRACT
Myeloid cell leukemia-1 (MCL-1) is an anti-apoptotic protein that plays a key role in promoting cell survival in multiple myeloma, acute myeloid leukemia and non-Hodgkin lymphoma. MCL-1 is highly expressed in a variety of hematological malignancies, which is one of the important factors leading to poor prognosis and chemoresistance in patients with hematological malignancies. Therefore, MCL-1 is an important therapeutic target for hematological malignancies. Several MCL-1 inhibitors have entered clinical trials, including S63845, AZD5991, S64315, AMG-176, and AMG-397. The treatment plans used for hematological malignancies include monotherapy with MCL-1 inhibitors, as well as combination therapy with B cell lymphoma 2 inhibitors or immunomodulatory drugs, all indicating that MCL-1 inhibitors may be a breakthrough point for targeted treatment of hematological malignancies.
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WPRIM
Language:
Zh
Journal:
Journal of International Oncology
Year:
2024
Type:
Article