Immunological abnormalities in patient with IgA nephropathy
Journal of Korean Medical Science
;
: 43-48, 1986.
Article
in English
| WPRIM
| ID: wpr-101859
ABSTRACT
T cell immunity and phagocytic activity were studied in the blood of patients with IgA nephropathy in order to clarify their roles in the pathogenesis of IgA nephropathy. The percentages of total T lymphocytes, helper T cell and suppressor T cells were significantly reduced in patients. A significantly elevated helper T cell/suppressor T cell ratio in patients showed a predominant reduction in suppressor T cells. There was a significant relationship between histologic findings and helper T cell/suppressor T cell ratio in patients. Natural Killer (NK) cell activity was significantly reduced but the lymphocyte response after phytohemagglutinin (PHA) stimulation was not in patients. ConA-induced suppressor cell activity was not depressed despite of a decrease in suppressor T cells in patients. Phagocytic activity of polymorphonuclear leucocytes (PMNs) ingesting yeasts was significantly reduced in patients. Also an inverse correlation was found between serum IgA levels and phagocytic activity of PMN. It is concluded that suppressor T cell defects, depressed phagocytic activity and impaired NK cell activity may play a role in the pathogenesis of IgA nephropathy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phagocytosis
/
B-Lymphocytes
/
Killer Cells, Natural
/
T-Lymphocytes
/
T-Lymphocytes, Regulatory
/
Glomerulonephritis, IGA
/
Neutrophils
Limits:
Humans
Language:
English
Journal:
Journal of Korean Medical Science
Year:
1986
Type:
Article
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