A Case of Pseudomenbranous Colitis after Paclitaxel and Carboplatin Chemotherapy / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 328-332, 2009.
Article
in Korean
| WPRIM
| ID: wpr-101883
ABSTRACT
Antibiotics-associated pseudomembranous colitis is well documented and caused by abnormal overgrowth of toxin producing Clostridium difficile colonizing the large bowel of patients undergoing antibiotic therapy. Administration of chemotherapeutic agents is frequently complicated by diarrhea and enterocolitis. However, pseudomembranous colitis related to chemotherapeutic agent usage is very rare. We experienced a 67 old-years male patient diagnosed of non-small cell lung carcinoma who complained of watery diarrhea and abdominal pain after treated with paclitaxel and carboplatin. Sigmoidoscopic examination revealed diffusely scattered, whitish to yellowish pseudo-membrane with background edematous hyperemic mucosa from sigmoid colon to rectum. Histopathologic findings were consistent with pseudomembranous colitis as typical volcano-like exudate. The symptoms improved after stopping chemotherapy and treatment with metronidazole. In patients with persistent diarrhea and abdominal pain after receiving chemotherapy agents, although rare, pseudomembranous colitis should be considered as a differential diagnosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Enterocolitis, Pseudomembranous
/
Antineoplastic Combined Chemotherapy Protocols
/
Tomography, X-Ray Computed
/
Carboplatin
/
Sigmoidoscopy
/
Paclitaxel
/
Carcinoma, Non-Small-Cell Lung
/
Diagnosis, Differential
/
Lung Neoplasms
/
Metronidazole
Type of study:
Diagnostic study
Limits:
Aged
/
Humans
/
Male
Language:
Korean
Journal:
The Korean Journal of Gastroenterology
Year:
2009
Type:
Article
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