One case report of a patient with anti-osteoporosis drug related hyperparathyroidism cured after strengthening calcium and vitamin D supplementation / 中华内分泌外科杂志

ABSTRACT

Anti-osteoporosis drug is important to treat osteoporosis. However, systemic musculoskeletal and joints pain and other adverse events in some patients are unrelieved or even aggravated after using anti-osteoporosis drugs, which may be associated with anti-osteoporosis drug related parathyroid hyperfunction or hyperparathyroidism. We report a case of 78 years old female with osteoporosis who, on the basis of conventional regular supplementation of Vitamin D and calcium supplements, presented with a decreased level of serum calcium and negative calcium balance after receiving anti-osteoporosis drugs, resulting in hyperparathyroidism, significant pain in bilateral knee joints and inability of walking independently. After sufficient supplementation of vitamin D and calcium, the pain was significantly relieved, bone metabolism indicators returned to normal, the patient was able to walk without assistance and had no recurrence after 1 year of follow-up.