Effects of Chili Treatment on Gastrointestinal and Rectal Sensation in Diarrhea-predominant Irritable Bowel Syndrome: A Randomized, Double-blinded, Crossover Study
Journal of Neurogastroenterology and Motility
;
: 400-406, 2014.
Article
in English
| WPRIM
| ID: wpr-101959
ABSTRACT
BACKGROUND/AIMS:
Whether, chronic chili ingestion can desensitize transient receptor potential vanilloid type 1 receptors in gastrointestinal (GI) tract leading to decrease GI symptoms and sensation in diarrhea-predominant irritable bowel syndrome (IBS-D) patients has not been well explored. The aim of this study was to determine the effects of 6-week chili treatment on postprandial GI symptoms and rectal sensation in response to balloon distention in IBS-D patients.METHODS:
Sixteen IBS-D patients received placebo or chili capsules before meals 3 times/day for 6 weeks in a randomized, double-blinded, crossover fashion with 4-week washout period. Postprandial GI symptoms were evaluated. All patients underwent a rectal barostat study to evaluate rectal sensory threshold at the end of each treatment.RESULTS:
The maximum postprandial abdominal burning scores were similar between both treatments at baseline (1.4 [0.0-2.0] vs. 1.1 [0.0-2.8], P > 0.05) but were significantly decreased after chili (0.0 [0.0-0.5] vs. 0.3 [0.0-1.6], P < 0.05) at the end of treatment. The chili treatment significantly increased sensory threshold for the first rectal sensation (median [interquartile range]16 [12-16] mmHg vs. 8 [8-16] mmHg, P < 0.05) however, there was no significant effect on rectal compliance (7.3 +/- 1.0 vs. 7.1 +/- 1.8 mL/mmHg). Other postprandial GI symptoms did not vary significantly between both treatments at baseline and the end of treatment.CONCLUSIONS:
In IBS-D patients, 6-week chili ingestion significantly decreased postprandial abdominal burning and increased the rectal sensory threshold. These findings suggest a desensitization effect of chili ingestion on transient receptor potential vanilloid type 1 receptors in the proximal gut and rectum.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rectum
/
Sensation
/
Sensory Thresholds
/
Burns
/
Capsules
/
Capsaicin
/
Compliance
/
Cross-Over Studies
/
Gastrointestinal Tract
/
Irritable Bowel Syndrome
Type of study:
Controlled clinical trial
Limits:
Humans
Language:
English
Journal:
Journal of Neurogastroenterology and Motility
Year:
2014
Type:
Article
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