Serial Plasma Levels of Angiogenic Factors in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
Korean Circulation Journal
;
: 464-470, 2012.
Article
in English
| WPRIM
| ID: wpr-102034
ABSTRACT
BACKGROUND AND OBJECTIVES:
Patients with acute myocardial infarction show varying degrees of collateral development. However, the relationships between angiogenic factors and degree of collaterals are not well known. SUBJECTS ANDMETHODS:
Fifty-nine patients (mean age, 59+/-10 years) with ST-segment elevation myocardial infarction (STEMI) underwent primary percutaneous coronary intervention (PCI). Patients were divided into one of 2 groups group I (Rentrop collateral grade 0/1, n=34) or group II (grade 2/3, n=25). Plasma levels of vascular endothelial growth factor (VEGF), soluble VEGF receptor (sFlt-1), angiopoietin (Ang)-2, and soluble Tie-2 at baseline, 24 and 48 hours after PCI were measured.RESULTS:
There were fewer diabetic patients and higher incidence of previous angina and multi-vessel disease in group II. Group II had a lower left ventricular ejection fraction and a trend toward longer pain-to-balloon time. Plasma levels of Ang-2, sFlt-1 were elevated prior to primary PCI and decreased after PCI, whereas plasma level of VEGF was relatively low initially, however rose after PCI. sTie-2 levels showed no significant interval change in group I, but decreased over time in group II. VEGF, sFlt-1, and Tie-2 levels did not differ between the groups at each time point. However, plasma levels of Ang-2 were higher in group I than in group II at baseline and at 48 hours.CONCLUSION:
Presence of collaterals in STEMI patients undergoing primary PCI was associated with lesser rise in Ang-2 plasma level. VEGF showed a delayed response to acute ischemia compared to Ang-2. Clinical implications of our findings need to be investigated in further studies.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Stroke Volume
/
Incidence
/
Receptors, Vascular Endothelial Growth Factor
/
Angiopoietin-2
/
Vascular Endothelial Growth Factor A
/
Angiogenesis Modulating Agents
/
Angiogenesis Inducing Agents
/
Percutaneous Coronary Intervention
/
Ischemia
Type of study:
Incidence study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Korean Circulation Journal
Year:
2012
Type:
Article
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