Analysis of dosimetric parameters of acute radiation enteritis in cervical cancer patients treated with con-current chemoradiotherapy / 实用医学杂志

ABSTRACT

Objective To explore the correlation between intestinal dose and acute radiation enteritis(ARE)in patients with cervical cancer received concurrent chemoradiotherapy,and optimize the dose limit of intestinal tissue.Methods 158 cervical cancer patients received concurrent chemoradiotherapy from 2014 to 2019 were selected in this study.According to CTCAE 5.0,patients with ARE≥grade 2 were classified as ARE≥grade 2 group,otherwise classified as ARE<grade 2 group.The intestinal dosimetric parameters of the two groups were recorded from the dose volume histogram.The correlation between ARE≥grade 2 and intestinal dosimetric param-eters were analyzed using univariate and multivariate logistic regression.Results Among the 158 cervical cancer patients received concurrent chemoradiotherapy,26 cases had grade 2 or above ARE(16.46%).The incidence of ARE≥grade 2 in patients with malnutrition and three-dimensional conformal radiotherapy was significantly higher than that in patients with well-nourished and intensity modulated radiotherapy(P<0.05).The bowelbag V5,V40 and the rectal V50 of cervical cancer patients with ARE≥grade 2 were significantly higher than those with ARE<grade 2(P<0.05).ROC curves showed that bowelbag V5 and V40 were significant predictors of ARE≥grade 2(AUC>0.7,P<0.05).Conclusions For patients with cervical cancer received concurrent chemoradiotherapy,the dose of bowelbag V5 and V40 should be considered to rationally optimize the dose of bowelbag in the radiotherapy plan,so as to reduce the incidence of ARE≥grade 2.