Application of metal-organic frameworks in implant surface modification / 中国组织工程研究

ABSTRACT

BACKGROUND:In recent years,metal-organic frameworks have been widely used in the biomedical field because of their unique properties,and metal-organic frameworks can be applied to implant surface modification for improving their biological properties and the surgery's success rate. OBJECTIVE:To introduce metal-organic frameworks commonly used in implant surface modification and the preparation and action mechanism of surgical implants modified by metal-organic frameworks. METHODS:The articles concerning metal-organic frameworks used in implant surface modification published from 2010 to 2023 were searched on PubMed,Web of Science and CNKI.Finally,64 articles were included for review. RESULTS AND CONCLUSION:(1)Metal-organic frameworks have the properties of high porosity,large specific surface area,and diverse spatial structure.As bioactive material,metal-organic frameworks have attracted much attention in tissue engineering and regenerative medicine.(2)The metal-organic frameworks commonly used in the field of implant surface modification include three types.Zeolitic imidazolate frameworks are commonly used as carriers,carrying various drugs and biomolecules.The MIL series are suitable for drug carriers and nanoenzymes.Bio-metal-organic frameworks have many applications because of their diverse structure and are characterized by excellent biosafety.(3)The preparation of implant materials modified by metal-organic frameworks can be mainly divided into two types:one is to incorporate metal-organic frameworks into pretreated implants;the other is to synthesize metal-organic frameworks in situ on pretreated implants.(4)Metal-organic frameworks on the implant surface could release their components,load drugs,catalyze active reactions,or combine with other materials,giving implants antibacterial and anti-inflammatory characteristics and promoting osseointegration.The preparation method of metal-organic framework coatings needs further improvement,and the metabolism and distribution of metal-organic framework coatings should be deeply explored,and its clinical application should be actively promoted.