Application of synthetic and biological materials in articular cartilage repair / 中国组织工程研究

ABSTRACT

BACKGROUND:The repair of articular cartilage injury remains a difficult problem to be solved urgently in clinical practice.Utilizing synthetic or biological materials to promote cartilage regeneration has been a research hotspot. OBJECTIVE:To review the research progress of synthetic and biological materials in articular cartilage repair. METHODS:PubMed and CNKI databases were searched for articles about the progress of synthetic and biological materials utilized in articular cartilage repair."Collagen,gelatin,silk,chitosan,alginate,PEG,PCL,PLA,cartilage tissue engineering,cartilage tissue engineering materials"were used as English and Chinese search terms,respectively.After preliminary screening based on the inclusion and exclusion criteria,98 articles with high quality and relevance were retained for review. RESULTS AND CONCLUSION:Natural materials,including collagen,gelatin,silk,chitosan,and alginate,have good biocompatibility and degradability.Synthetic materials,containing polyethylene glycol,polycaprolactone,and polylactic acid,have good mechanical properties.Modification and composition of materials can overcome the inherent defects in materials and show better cartilage repair ability.Studies about multi-layer scaffolds based on hierarchical structure are rare,and it is more targeted at osteochondral injury repair rather than simple cartilage injury repair.At present,scaffold research is focused on the synthetic research and development stage,and the corresponding clinical trials are few,so it is necessary to pay attention to clinical transformation in the future.