Exploration of the significance of NOX4 in the evaluation of gastric cancer / 中国现代普通外科进展
Chinese Journal of Current Advances in General Surgery
; (4): 36-41, 2024.
Article
in Zh
| WPRIM
| ID: wpr-1025410
Responsible library:
WPRO
ABSTRACT
Objective:This article is to investigate NADPH oxidase 4(NOX4)expression,prog-nosis,signaling pathway and key immune cells infiltrating in tumor tissues in gastric cancer.Meth-ods:Data were downloaded from the Cancer Genome Atlas(TCGA)and the Integrated Gene Ex-pression Database(GEO).The expression of NOX4 in gastric cancer and normal tissues,the rela-tionship between NOX4 expression level and clinical characteristics of patients,gene enrichment analysis of signaling pathways and immune infiltration analysis have been analyzed.Results:In terms of NOX4 expression,tumor tissue is significantly higher than normal tissue,which has certain diagnostic value;NOX4 is an important prognostic factor with poor prognosis in patients with high NOX4 expression;NOX4 is associated with cell adhesion molecules(CAMs),transforming growth factor-β(TGF-β),and WNT signaling pathway.NOX4 high expression group was mainly related to M2 macrophages and plasma cell infiltration in tumor tissues.Conclusion:NOX4 plays an impor-tant role in the progression of gastric cancer(GC).
Full text:
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Current Advances in General Surgery
Year:
2024
Type:
Article