Correlation between serum 25-hydroxyvitamin D3 and the severity of atopic dermatitis in children with allergic or nonallergenic sensitization
Allergy, Asthma & Respiratory Disease
;
: 213-218, 2015.
Article
in Korean
| WPRIM
| ID: wpr-102769
ABSTRACT
PURPOSE:
The aim of this study was to assess the relationship between serum 25-hydroxyvitamin D3 levels and the severity of atopic dermatitis (AD), markers of atopy (total IgE, total eosinophil count, and eosinophil cationic protein) in AD children according to allergen sensitization.METHODS:
This cross-sectional study was carried out on 160 AD patients aged 1 to 18 years between March 2012 and August 2014. The AD patients (AD group) were subdivided into 2 categories according to the results of the allergic skin prick and Unicap tests the allergic and nonallergic AD groups. We compared 25-hydroxyvitamin D3 levels between the AD and control groups. We also investigated relationships between serum 25-hydroxyvitamin D3 levels, the severity of AD, and markers of AD (total IgE, total eosinophil count, and eosinophil cationic protein) in the allergic and nonallergic AD groups.RESULTS:
The average 25-hydroxyvitamin D3 levels were 30.6+/-11.7 and 23.7+/-10.0 ng/mL, respectively, in the control and AD groups (P<0.001). The average 25-hydroxyvitamin D3 levels were 19.7+/-8.6 and 27.5+/-9.8 ng/mL, respectively, in the allergic and nonallergic AD groups, with clinical implications (P<0.001). The 25-hydroxyvitamin D3 levels were not significantly associated with SCORing Atopic Dermatitis index in the allergic (P=0.004, r=-0.092) or nonallergic (P=0.610, r=-0.58) AD groups. The 25-hydroxyvitamin D3 levels were not significantly associated with the aforementioned markers of atopy in the AD group.CONCLUSION:
These results suggest that 25-hydroxyvitamin D3 may play a role in the pathogenesis of AD.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Skin
/
Calcifediol
/
Immunoglobulin E
/
Allergens
/
Cross-Sectional Studies
/
Dermatitis, Atopic
/
Eosinophils
Type of study:
Observational study
/
Prevalence study
/
Risk factors
Limits:
Child
/
Humans
Language:
Korean
Journal:
Allergy, Asthma & Respiratory Disease
Year:
2015
Type:
Article
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