The Clinical Effects of Tranilast on Restenosis after Percutaneous Transluminal Coronary Angioplasty
Korean Circulation Journal
;
: 1274-1280, 2001.
Article
in Korean
| WPRIM
| ID: wpr-102903
ABSTRACT
BACKGROUND AND OBJECTIVES:
Tranilast is an anti-allergic drug that suppresses the release of cytokines, such as platelet-derived growth factor, transforming growth factor-beta and interleukin-1beta. It has recently become known to be effective in the prevention of restenosis following PTCA (percutaneous transluminal coronary angioplasty). SUBJECTS ANDMETHODS:
One hundred forty two consecutive patients with angina who underwent PTCA between Jan 1999 and Jul 2000 at Chonnam National University Hospital were analyzed prospectively. Thirty patients (Tranilast group60.8+/-7.7 years, MF=228, 41 lesions) out of 48 who received 300 mg tranilast for 3 months following PTCA and who underwent follow-up CAG (coronary angiogram), were compared with 61 patients (Control group58.1+/-11.0 years, MF=529, 82 lesions) out of 94, 94 who did not receive tranilast but did undergo follow-up CAG.RESULTS:
The restenosis rate per lesion was significantly lower in the Tranilast group than in the Control group on the 6-month follow-up CAG (Tranilast vs. Control group19.5% vs. 40.2%, p=0.021). The minimal luminal diameter was significantly larger in the Tranilast group as compared to the Control group (1.99+/-0.76 vs. 1.50+/-0.83 mm p=0.002). One patient of the Tranilast group suffered from liver dysfunction and stopped medication.CONCLUSION:
The oral administration of tranilast is safe and effective in the prevention of restenosis following PTCA in patients with angina.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenobarbital
/
Platelet-Derived Growth Factor
/
Angioplasty, Balloon, Coronary
/
Administration, Oral
/
Prospective Studies
/
Follow-Up Studies
/
Cytokines
/
Coronary Disease
/
Interleukin-1beta
/
Liver Diseases
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Korean Circulation Journal
Year:
2001
Type:
Article
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