Fatal PTLD Accompanied by Rapid Lymphocyte Proliferation in the Early Phase of Allogeneic HSCT / 대한내과학회지
Korean Journal of Medicine
;
: 243-248, 2015.
Article
in English
| WPRIM
| ID: wpr-102974
ABSTRACT
Post-transplant lymphoproliferative disorder (PTLD) is a spectrum of clinically and morphologically heterogeneous lymphoid proliferations of various clonal compositions that are observed after hematopoietic stem cell transplantation (HSCT) or solid organ transplantation. The majority of PTLD cases are associated with Epstein-Barr virus (EBV) infection, while overt peripheral blood (PB) or bone marrow (BM) involvement in PTLD is uncommon in early lesions. We report a 38-year-old woman with EBV-related PTLD, with BM and PB involvement, who presented with peripheral lymphocytosis as an early lesion 1 month after haploidentical HSCT for Philadelphia chromosome-positive acute lymphoblastic leukemia was performed during first complete remission. Although PB or BM involvement of PTLD after HSCT is uncommon in early lesions, peripheral lymphocytosis can be an initial presenting manifestation of PTLD, as in this case.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Transplantation
/
Bone Marrow
/
Lymphocytes
/
Organ Transplantation
/
Herpesvirus 4, Human
/
Hematopoietic Stem Cell Transplantation
/
Transplants
/
Epstein-Barr Virus Infections
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
Lymphocytosis
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
Korean Journal of Medicine
Year:
2015
Type:
Article
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