Relation of the Expression of Cyclooxygenase-2 in Colorectal Adenomas and Adenocarcinomas to Angiogenesis and Prognosis
Journal of the Korean Society of Coloproctology
;
: 339-346, 2010.
Article
in English
| WPRIM
| ID: wpr-103039
ABSTRACT
PURPOSE:
Recent studies have shown that cyclooxygenase (COX)-2 may be involved in tumor growth, invasion and apoptosis in various carcinomas. Vascular endothelial growth factor (VEGF) has a potent angiogenic activity, and COX-2 promotes angiogenesis by modulating angiogenic factors, including VEGF. Endothelial growth factor receptor (EGFR) is considered as a factor of cell growth, maturation and cell death. The current study was designed to investigate the possible roles of COX-2 in colorectal tumor progression and angiogenesis.METHODS:
Fifty colorectal adenomas and forty adenocarcinomas were investigated by using immunohistochemical staining for COX-2, VEGF and EGFR. The correlations of COX-2, VEGF and EGFR with the grade of dysplasia, the size of the adenoma, and various clinicopathologic factors were studied.RESULTS:
The expressions of COX-2, VEGF and EGFR were each significantly correlated with carcinomatous transformation, and the expressions of COX-2 and VEGF were significantly correlated. COX-2 and EGFR showed correlations with adenomas rather than adenocarcinomas. However, no correlations of COX-2, VEGF and EGFR expression to other clinicopathologic factors, except tumor size in EGFR expression, were detected.CONCLUSION:
These results suggest that COX-2 may play an important role in carcinogenesis through interaction with VEGF and EGFR in human colorectal cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Colorectal Neoplasms
/
Adenocarcinoma
/
Adenoma
/
Cell Death
/
Prostaglandin-Endoperoxide Synthases
/
Apoptosis
/
Receptors, Vascular Endothelial Growth Factor
/
Vascular Endothelial Growth Factor A
/
Angiogenesis Inducing Agents
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Journal of the Korean Society of Coloproctology
Year:
2010
Type:
Article
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