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Diagnostic value of lysine-aspirin bronchoprovocation test for aspirin-sensitive asthma / 알레르기
Korean Journal of Allergy ; : 171-179, 1997.
Article in Korean | WPRIM | ID: wpr-103172
ABSTRACT
Aspirin(ASA) and NSAIDs can induce bronchoconstriction in 10~20% of adult asthmatics patients. Inhalation of lysine-ASA(L-ASA) has been described as an alternative method for diagnosis of ASA-sensitive asthma. To further understand the characterlstics of ASA-sensitive asthmas. we studied 38 asthmatic patients with ASA -sensitivity (36 intrinsic and 2 extrinsic asthma) proven by L-ASA bronchoprovocation test (BPT). Most were female (male to female ratio was 2773). Twenty (53%) of them had no previous history of adverse reactions when exposed to ASA. Twenty nine (79%) had rhino-sinusitis symptoms. Early asthmatic response was observed in 16 (42%) patients, late only response in 16(42%), and dual response in 6(16%) patients. The threshold of L-ASA to provoke a positive response ranged from 11.2 to 180 mg/ml and most (68.3%) had a positive response after the inhalation of 180 mg/ml. Concurrent sensitivity to sulfite was noted in 14 (36%) patients, followed by sensitivity to tartrazine in one (3%) patient. None showed a positive response to sodium benzoate. After the avoidance from ASA/ NSAIDs with administration of anti-asthmatic medications, symptom and medication scores reduced in 26(87%) patients among 30 followed patients. They were classified into the improved group four (13%) patients belonged to the not-improved group. There were no significant differences in clinical characteristics between the improved and not- improved group (p>0.05). In conclusion, L-ASA BPT could be considered as a useful method to diagnose ASA -sensitive asthma and be used to screen the causative agent for asthmatic patients with intrinsic type, especially in female patients with rhino-sinusitis and/or nasal polyp, even though they do not have arty history of adverse reactions. Cessation of exposure and proper treatment may allow to reduce symptom and medication scores.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Asthma / Tartrazine / Inhalation / Anti-Inflammatory Agents, Non-Steroidal / Nasal Polyps / Bronchoconstriction / Sodium Benzoate / Diagnosis Type of study: Diagnostic study Limits: Adult / Female / Humans Language: Korean Journal: Korean Journal of Allergy Year: 1997 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Asthma / Tartrazine / Inhalation / Anti-Inflammatory Agents, Non-Steroidal / Nasal Polyps / Bronchoconstriction / Sodium Benzoate / Diagnosis Type of study: Diagnostic study Limits: Adult / Female / Humans Language: Korean Journal: Korean Journal of Allergy Year: 1997 Type: Article