Therapeutic effect of pramipexole in Parkinson's disease / 中华神经医学杂志

ABSTRACT

Objective To study the therapeutic effect of pramipexole in Parkinson's disease (PD). Methods Forty patients with PD were treated with pramipexole for 12 weeks and evaluated with Unified Parkinson's Disease Rating Scale (UPDRS) before and after therapy.Among them, 6 cases were treated with pramipexole without any anti-PD drugs, and the rest with pramipexole and other anti-PD drugs. Some cases received follow-up at week 2, 4, 8, 12 to evaluate the therapeutic effect.Results After the therapy ofpramipexole, the symptoms of PD were alleviated in 35 patients (87.5％).The alleviation was statistically significant in UPDRS scores, daily activities, motor function, trembling,splinting, mental symptoms and on-off phenomenon.Futhermore, the post-therapeutic follow-up revealed that the patients get much better. Conclusions Pramipexole is effective in the treatment of PD.It is a safety and good effctive anti-parkinson drug.