Antiosteoporotic activity of Salvadora persica sticks extract in an estrogen deficient model of osteoporosis
Osteoporosis and Sarcopenia
;
: 132-137, 2017.
Article
in English
| WPRIM
| ID: wpr-103255
ABSTRACT
OBJECTIVES:
The effect of Salvadora persica sticks on prevention of tooth decay is well established, but the effect of S. persica stick extract (SPE) on the prevention/treatment of osteoporosis has not been studied. The purpose of this study is to provide baseline information of the effectiveness of SPE on ovariectomized (OVX) rat model of osteoporosis.METHODS:
SPE was administered at 50, 150, and 300 mg/d orally to OVX rats for 16 weeks. Serum osteocalcin, alkaline phosphatase, calcium, and phosphorus, and urinary deoxypyridinoline, calcium, and phosphorus were measured. Bone mineral density (BMD), 3-point bending test, and histomorphometric characteristics of the femoral bone were also examined.RESULTS:
SPE at doses of 150 and 300 mg/d, but not 50 mg/d, significantly prevented bone loss in OVX rats as proved by decreased biochemical markers of bone resorption and increased BMD and biomechanical indices of the femoral bone.CONCLUSIONS:
This study confirms a dose-dependent protective action of SPE on rat OVX model of osteoporosis. This effect needs further investigation at the molecular and clinical levels to provide a natural and cost-effective alternative for the management of postmenopausal osteoporosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoporosis
/
Phosphorus
/
Tooth
/
Bone Resorption
/
Ovariectomy
/
Biomarkers
/
Bone Density
/
Osteocalcin
/
Osteoporosis, Postmenopausal
/
Calcium
Type of study:
Prognostic study
Limits:
Animals
/
Female
/
Humans
Language:
English
Journal:
Osteoporosis and Sarcopenia
Year:
2017
Type:
Article
Similar
MEDLINE
...
LILACS
LIS