Continuous blood purification for treatment of pediatric cerebral disease with hypernatremia / 中华神经医学杂志

ABSTRACT

Objective To assess the value of continuous blood purification(caP)for treatment of pediatric cerebral disease complicated by hypernatremia. Methods Nine children with cerebral disease and concurrent hypematremia admitted in the pediatric intensive care unit received CBP therapy.The sodium concentration in the exchange fluid was adjusted according to the serum sodium concentration.The correlation between the serum sodium concentration and the disease condition of the children was analyzed,and the changes in sgrum sodium and hemodynamics after CBP were observed.Results Nine children showed significantly decreased sernm sodium after CBP therapy(P＜0.05).No significant changes in the hemodynamics wgre observed during CBP in these children(P＜0.05),whose disease condition remained stable.The serum sodium Was decreased by 14.2 mmol/L daily,and lowered at the mte of 0.75 mmol/L per hour.Of the 9 children,4 died of multiple organ dysfunction syndrome,1 gave up the treatment,and 4 recovered,with a cure rate of 44.44%. Conclusion As a safe and effective treatment modality for critical patients with hypernatremia,CBP must be carried out as early as possible especially in patients with cerebral disease complicated by hypematremia.