An EEG-fMRI study of centrotemporal spikes patients with benign childhood epilepsy / 中华神经医学杂志

ABSTRACT

Objective To study the blood oxygen dependent level (BOLD) changes associated with interictal spikes in benign childhood epilepsy patients with centrotemporal spikes (BCECTS).Methods BCECTS patients with frequent interictal spikes,admitted to our hsopital from Junary 2010 to December 2011,were included in our study; all the patients were performed simultaneous EEG combined functional magnetic resonance imaging (EEG-fMRI).The off-line EEG was filtered to find the time of spikes discharges,and then,the spike-related BOLD changes were calculated with the classic oxygen dynamics reaction function (HRF) model in statistical parametric mapping (SPM) software.Results Six patients with BCECTS were included with frequent spikes in the centrotemporal area in conventional EEG.One patient did not show spike discharge in EEG-fMRI scanning.Five patients showed BOLD signal changes in 5 sessions of fMRI.Activation signals were revealed in bilateral central temporal region in 2 sessions and in unilateral central temporal region in 3 sessions.The maximum activations were located in the centrotemporal area in 4 sessions and one session in the occipital lobe.The activation signals were observed in the other brain regions besides the central temporal regions in all the 5 patients.Conclusion The central temporal region may be the epileptogenic zone of BCECTS; the epileptogenic zone and other brain structures may contribute to the neural network of BCECTS.