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Regulation of c-Jun signaling pathway in peripheral nerve demyelination / 中华神经医学杂志
Chinese Journal of Neuromedicine ; (12): 1071-1075, 2016.
Article in Zh | WPRIM | ID: wpr-1034474
Responsible library: WPRO
ABSTRACT
After peripheral nerve injury (PNI),myelinated Schwann cells undergo demyelination,dedifferentiation and proliferation,then migrate along basal lamina tubes and align to form the longitudinal cell strands known as bands of Btüngner,which creates suitable conditions for axonal regeneration and remyelination.By reviewing literature,we found that the expression of a transcriptional factor c-Jun increased during demyelination process after PNI,and increasing evidences suggested that demyelination and c-Jun signaling pathways were closely related.This review summarized the research situation and progress of c-Jim signaling pathways regulating demyelination process after peripheral nerve injury.
Key words
Full text: 1 Index: WPRIM Language: Zh Journal: Chinese journal of neuromedicine Year: 2016 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: Chinese journal of neuromedicine Year: 2016 Type: Article