Changes on the urinary Prostaglandin E2 Values in the Upper Urinary Calculi / 대한비뇨기과학회지

ABSTRACT

Although some recent studies showed that increased synthesis of vasodilatory prostaglandin E2 were possible factor in the maintenance of renal blood flow during the states of impaired renal perfusion. However this fact is not studied in cases of upper urinary tract calculi yet. This study is to estimate the value of urinary prostaglandin E2 in cases of upper urinary calculi. The amount of prostaglandin E2 in urinary excretion was measured by radioimmunoassay in ten cases of complete ureteral obstruction compared with normal side, in eleven cases of partial ureteral obstruction compare with normal side and in three cases of bilateral renal calculi. The results obtained were summerized as follows 1. The values of urinary prostaglandin E2 were highly elevated in cases of bilateral renal calculi. 2. In ten cases of complete ureteral obstruction, the values of urinary prostaglandin E2 decreased in comparison with those of the normal side. 3. In eleven cases of partial obstructions of the ureter, urinary prostaglandin 2, values were elevated than those of the normal side.