Clinicopathologic analysis of papillary glioneuronal tumor / 中华神经医学杂志

ABSTRACT

Objective To investigate the clinicopathological features and prognoses of papillary glioneuronal tumor (PGNT), and to improve the understanding of clinical worker on the tumor. Methods Three patients with PGNT got conformation in our center from July 1, 2011 to Apral 20, 2019, were chosen. The clinical features, histopathological characteristics, immunohistochemical findings, and prognoses of these patients were retrospectively analyzed. Results Two patients were female and one was male. Two tumors were located in the lateral ventricle and one in the temporal lobe. All patients presented with headache, and two exhibited dizziness. Imaging showed solid or cystic mass with well-defined boundary. Microscopically, it was characterized by papillary structures covered by single to multiple layers of small cuboidal gliocytes, and neurocyte-like cells scattered between the papilla. Immunohistochemically, the tumor cells covering papilla were positive for glial fibrillary acidic protein and oligodendrocyte transcription factor 2, and neurocyte-like cells were positive for synaptophysin; and the tumor cells were negative for isocitrate dehydrogenase 1 and silk/threonine specific protein kinase gene BRAF V600E. The proliferating cell nuclear antigen Ki-67 labeling index ranged from 1％-2％. Three patients were followed up for 12, 24 and 48 months after tumor resection, respectively, and no recurrence was found. Conclusion PGNT is an uncommon and variant of mixed neuronal-glial neoplasm with low-grade malignancy; the prognosis is good after gross total resection.