IL-33 Priming Enhances Peritoneal Macrophage Activity in Response to Candida albicans
Immune Network
;
: 201-206, 2014.
Article
in English
| WPRIM
| ID: wpr-103516
ABSTRACT
IL-33 is a member of the IL-1 cytokine family and plays a role in the host defense against bacteria, viruses, and fungi. In this study, we investigated the function of IL-33 and its receptor in in vitro macrophage responses to Candida albicans. Our results demonstrate that pre-sensitization of isolated peritoneal macrophages with IL-33 enhanced their pro-inflammatory cytokine production and phagocytic activity in response to C. albicans. These macrophage activities were entirely dependent on the ST2-MyD88 signaling pathway. In addition, pre-sensitization with IL-33 also increased ROS production and the subsequent killing ability of macrophages following C. albicans challenge. These results indicate that IL-33 may increase anti-fungal activity against Candida through macrophage-mediated resistance mechanisms.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phagocytosis
/
Bacteria
/
Candida
/
Candida albicans
/
Interleukin-1
/
Macrophages, Peritoneal
/
Fungi
/
Homicide
/
Macrophages
Limits:
Humans
Language:
English
Journal:
Immune Network
Year:
2014
Type:
Article
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