Phenotype of peroxisome proliferator-activated receptor-alpha(PPARalpha)deficient mice on mixed background fed high fat diet
Journal of Veterinary Science
;
: 239-244, 2003.
Article
in English
| WPRIM
| ID: wpr-103635
ABSTRACT
Considerable controversy exists in determining the role of peroxisome proliferator-activated receptor-alpha(PPARalpha) on obesity. Previous reports demonstrated that PPARalpha is a critical modulator of lipid homeostasis, but the overt, obese phenotypic characterization in the strain of PPAR deficient (PPARalpha-/-) mice is influenced by other factors, including diet and genetics. Therefore, it is necessary to establish the phenotypic characterization of PPARalpha-/- mice prior to the obesity-related study. In this study, we observed phenotype of PPARalpha-/- mice on mixed genetic background (C57BL/6Nx129/Sv) fed a high fat diet for 16 weeks. PPARalpha-/- mice, regardless of sex, raised body growth rate significantly comparing with wild type and showed male-specific fatty change in the liver. They were shown to lack hepatic induction of PPARalpha target genes encoding enzymes for fatty acid beta-oxidation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenotype
/
Transcription Factors
/
Triglycerides
/
Body Weight
/
RNA
/
Dietary Fats
/
Adipose Tissue
/
Cholesterol
/
Specific Pathogen-Free Organisms
/
Receptors, Cytoplasmic and Nuclear
Limits:
Animals
Language:
English
Journal:
Journal of Veterinary Science
Year:
2003
Type:
Article
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