Clinical study on insulin resistance associated with colorectal cancer / 中国现代医生

ABSTRACT

Objective To study insulin resistance and colorectal cancer (CRC) clinical features, pathological characteristics and hazards. Methods A total of 322 cases of CRC patients and 200 healthy subjects divided into CRC group and control group, BMI, WHR, SBP, DBP, FPG, FINS, HOMA-IR, TC, TG, HDL-C, LDL-C, adiponectin of two groups were compared, and to analyze the risk factors of CRC and insulin resistance and pathological features of CRC. Results CRC group, WHR, SBP, FPG, FINS, HOMA-IR, TG values were significantly higher (P<0.05), HDL-C, adiponectin were significantly lower than the control group (P<0.05). Two BMI, DBP, TC, LDL-C values, the difference were not statistically significant (P> 0.05). Family history, metabolic syndrome, FINS, HOMA-IR were risk factors for CRC(P<0.05). Insulin resistance and TNM stage(P<0.05), and not related to tumor location, differentiation, lymph node metastasis, distant metastasis (P>0.05). Conclusion Insulin resistance, family history, prevalence of metabolic syndrome and colorectal cancer is closely related to the degree of insulin resistance may be associated with the progression of colorectal cancer.