Influence of nifedipine extended release tablets combined with indapamide tablets on blood pressure and renal function of patients with primary hy-pertension / 中国现代医生

ABSTRACT

Objective To analyze the influence of nifedipine extended release tablets combined with indapamide tablets on the blood pressure and renal function of patients with primary hypertension. Methods A total of 117 patients with primary hypertension were randomly divided into two groups. The control group was given nifedipine extended release tablets and the experimental group was given nifedipine extended release tablets combined with indapamide tablets. Three months later, the comprehensive efficacy, blood pressure changes, renal function indicators and adverse drug re-actions of the two groups were compared. Results The total effective rate of the experimental group was 91.53%, which was higher than the 75.86% of the control group, with statistically significant difference (P<0.05). The experimental group had lower influence on the blood pressure and renal function than the control group (P<0.01). The incidence of adverse reactions of the experimental group was 10.17%, The control group was 8.62%, there was not statisticatly sig-nificant.difference (P>0.05). Conclusion In the treatment of primary hypertension, nifedipine extended release tablets combined with indapamide tablets shows accurate efficacy in reducing and controlling blood pressure, can increase re-nal blood flow volume to reduce renal damage, and is safe and reliable.