The Effect of Androsterone as the Metabolite of Testosterone to Seizure Suppression
Journal of the Korean Neurological Association
;
: 142-146, 2009.
Article
in Korean
| WPRIM
| ID: wpr-103701
ABSTRACT
BACKGROUND:
Androsterone is one of the major metabolites from testosterone whose clinical importance remains unclear. This study evaluated the effects of androsterone on seizure susceptibility in mouse models of epilepsy.METHODS:
The efficacy of androsterone (10~200 mg/kg, i.p.) against seizures induced by various GABA receptor antagonists and glutamate receptor agonists was evaluated.RESULTS:
Androsterone protected mice against seizures induced by PTZ (pentylenetetrazol), PCX (picrotoxin), and DMCM (methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate) in a dose-dependent manner. Androsterone did not protect against seizures induced by kainic acid, NMDA (N-methyl-D-aspartic acid), or 4-AP (4-aminopyridine) in mice.CONCLUSIONS:
These results suggest that androsterone exhibits anticonvulsant activity that occurs largely via nongenomic mechanisms. Testosterone-derived androsterone might be an endogenous protective neuroactive steroid in the brain.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Seizures
/
Testosterone
/
Carbolines
/
N-Methylaspartate
/
Receptors, Glutamate
/
GABA Antagonists
/
Epilepsy
/
Gamma-Aminobutyric Acid
/
Androsterone
/
Kainic Acid
Limits:
Animals
Language:
Korean
Journal:
Journal of the Korean Neurological Association
Year:
2009
Type:
Article
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