Expression and significance of NF-κB p65 in endometriosis lesions / 中国现代医生

ABSTRACT

Objective To explore the expressions and significance of NF-κB p65 in different place endometriosis.Methods A total of 48 specimans with endometriosis (16 cases of extrapelvic endometriosis,32 cases of ovarian en-dometriosis and meanwhile 22 cases of eutopic endometrium) were enrolled in the study,20 cases of normal en-dometrium were involed as control group. Immunoh istochemistry was used to detect the expressions of NF-κB p65 in above groups. Results The expressions of NF-κB p65 were found in the glandular epithelial cells in all groups. The ex-trapelvic endometriosis cases showed the highest expression,followed by ectopic endometrium, eutopic endometrium,and showing the lowest in normal endometrium,the difference among those groups was significant (P<0.05). However,the difference between prolificative phase and secretory phase was not significant (P>0.05). Furthermore, there was no correlation with clinical stages in ovarian endometriosis. Conclusion NF-κB p65 proteins are highly expressed in extrapelvic and ectopic endometrium,which suggests that they may participate in the development and progression of endometriosis.