Association between Plasma Levels of Plasminogen Activator Inhibitor-1 and Colorectal Neoplasms
Gut and Liver
;
: 519-523, 2013.
Article
in English
| WPRIM
| ID: wpr-103746
ABSTRACT
BACKGROUND/AIMS:
Plasminogen activator inhibitor-1 (PAI-1) is important for tumor growth, Invasion, and metastasis. In this study, we investigated the relationship between plasma levels of PAI-1 and colorectal adenomas.METHODS:
We reviewed the medical records of 3,136 subjects who underwent colonoscopy as a screening exam. The subjects were classified into a case group with adenomas (n=990) and a control group (n=2,146). Plasma PAI-1 levels were categorized into three groups based on tertile.RESULTS:
The plasma levels of PAI-1 were significantly higher in adenoma cases than in controls (p=0.023). The prevalence of colorectal adenomas increased significantly with increasing levels of PAI-1 (p=0.038). In the adenoma group, advanced pathologic features, size, and number of adenomas did not differ among the three groups based on tertiles for plasma PAI-1 levels. Using multivariate analysis, we found that plasma level of PAI-1 was not associated with the risk of colorectal adenomas (p=0.675). Adjusted odds ratios for colorectal adenomas according to increasing plasma levels of PAI-1 were 0.980 (95% confidence interval [CI], 0.768 to 1.251) for the second-highest plasma level and 1.091 (95% CI, 0.898 to 1.326) for the highest level, compared with the lowest levels.CONCLUSIONS:
These results suggest that elevated plasma PAI-1 levels are not associated with the risk of colorectal neoplasms.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Plasminogen
/
Plasminogen Activators
/
Colorectal Neoplasms
/
Adenoma
/
Odds Ratio
/
Mass Screening
/
Medical Records
/
Prevalence
/
Multivariate Analysis
Type of study:
Etiology study
/
Prevalence study
/
Prognostic study
/
Screening study
Language:
English
Journal:
Gut and Liver
Year:
2013
Type:
Article
Similar
MEDLINE
...
LILACS
LIS