SOX9 Is Highly Expressed in Nonampullary Duodenal Adenoma and Adenocarcinoma in Humans
Gut and Liver
;
: 513-518, 2013.
Article
in English
| WPRIM
| ID: wpr-103747
ABSTRACT
BACKGROUND/AIMS:
SOX9 is a marker for stem cells in the intestine, and overexpression of SOX9 is found in gastric and colon cancer; however, the expression of SOX9 in nonampullary duodenal adenoma and adenocarcinoma has not yet been evaluated. This study aimed to investigate SOX9 expression in nonampullary duodenal adenoma and adenocarcinoma by immunohistochemistry.METHODS:
We evaluated SOX9 expression in 43 clinical samples (nonampullary duodenal adenoma in 22 lesions and nonampullary duodenal adenocarcinoma in 21 lesions) resected under endoscopic mucosal resection or endoscopic submucosal dissection.RESULTS:
SOX9 was expressed in part of the base of the normal duodenal mucosa surrounding adenomas and adenocarcinomas. In contrast, SOX9-positive cells were found in more than half of the crypts from the bottom part of the crypt in all of the 43 samples. Moreover, in 15 adenoma samples (68.2%) and 19 carcinoma samples (90.5%), SOX9 was expressed in more than three-quarters of the crypts from the bottom part of the crypt.CONCLUSIONS:
SOX9 is overexpressed in nonampullary duodenal adenoma and adenocarcinoma in humans.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Stem Cells
/
Adenocarcinoma
/
Adenoma
/
Colon
/
Intestines
/
Mucous Membrane
Limits:
Humans
Language:
English
Journal:
Gut and Liver
Year:
2013
Type:
Article
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