The influence of Atorvastatin plus Probucol on carotid atherosclerotic plaque and plasma ox-LDL / 中国现代医生

ABSTRACT

Objective To study the influence of Atorvastatin plus Probucol on carotid atherosclerotic plaque and plasma ox-LDL. Methods One hundred and twenty eight patients with carotid atherosclerotic plaque formation were randomly divided into two groups,64 cases in each group. Patients in the treatment group were treated with Atorvastatin plus Probucol, patients in the control group were treated with Atorvastatin alone. The plaque area,lipid and ox-LDL were measured before and 52 weeks after treatment. Results Finally 122 cases were included in the statistics.Before treat-ment there was no significant difference between two groups on carotid plaque area,lipid levels and ox-LDL level(P>0.05). But after 52 weeks treatment, the difference were remarkable(P<0.01). Conclusion Probucol combined with ator-vastatin in the treatment of carotid atherosclerotic plaque is better than pure atorvastatin treatment.Combination therapy can achieve the anti atherosclerosis plaque stability, anti oxidative stress, radical and lower ischemic cardio cerebral vascular disease objective.