Drug-Induced Anaphylaxis in a Single Korean Tertiary Hospital / 대한내과학회지
Korean Journal of Medicine
;
: 281-287, 2015.
Article
in Korean
| WPRIM
| ID: wpr-103794
ABSTRACT
BACKGROUND/AIMS:
Drug-induced anaphylaxis (DIA) is a severe, acute, and potentially life-threatening condition. In Korea, only a few well-documented cases of DIA have been described. Therefore, the aim of this study was to investigate the clinical characteristics, causes, and management of DIA in a single Korean medical institute.METHODS:
This was a retrospective medical record review of all DIA patients who visited the in-patient, out-patient, and emergency departments of our hospital from January 1 2006 to October 30 2013.RESULTS:
Among 605 cases of anaphylaxis, 167 were drug-induced. The culprit drugs were contrast agents (43 cases, 25.7%), antibiotics (38, 22.8%), non-steroidal anti-inflammatory drugs (35, 21.0%), anti-cancer drugs (22, 13.2%), parenteral vitamins (9, 5.4%), ranitidine (6, 3.6%), and neuromuscular blockers (3, 1.8%). The most common organ-specific symptoms/signs were cardiovascular (74.3%), cutaneous (71.3%), respiratory (55.7%), and gastrointestinal manifestations (19.2%). In most cases, DIA was treated with antihistamines (77.2%) and systemic corticosteroids (76.5%); the use of epinephrine was considerably less frequent (35.3%).CONCLUSIONS:
In our institution, contrast agents were the leading cause of DIA. Although epinephrine is the drug of choice in the treatment of acute anaphylaxis, fewer than 50% of the study patients received epinephrine to treat DIA.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Outpatients
/
Ranitidine
/
Vitamins
/
Epinephrine
/
Medical Records
/
Epidemiology
/
Retrospective Studies
/
Adrenal Cortex Hormones
/
Contrast Media
/
Neuromuscular Blockade
Type of study:
Observational study
Limits:
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2015
Type:
Article
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