Clinical study on non-drug treatment of BPSD in senile dementia and its correlation with ApoE gene polymorphism / 中国现代医生

ABSTRACT

Objective To analyze the effect of non-drug therapy on behavioral and psychological symptom of dementia(BPSD)and its correlation with apolipoprotein E(ApoE)gene polymorphism.Methods A total of 90 patients with senile dementia admitted to Jiangxi Provincial People's Hospital from January 2016 to December 2022 were selected as study objects,they were divided into routine group,control group and observation group according to random number table method,with 30 cases in each group.Patients in routine group were treated with memantine hydrochloride tablets,patients in control group were treated with music therapy on the basis of routine group,patients in observation group were treated with repeated transcranial magnetic stimulation on the basis of routine group,and they were all treated for 12 weeks.BPSD severity,dementia severity,cognitive function,ability of daily living and ApoE gene polymorphism were compared among the three groups.Results Before treatment,there were no significant differences in the scores of neuropsychiatric inventory(NPI),clinical dementia rating(CDR),mini-mental state examination(MMSE)and activity of daily living(ADL)scale among the three groups(P>0.05).After treatment,the NPI and CDR scores of three groups were significantly lower than before treatment,and the MMSE and ADL scores were significantly higher than before treatment(P<0.05).The scores of NPI and CDR in observation group and control group were significantly lower than those in routine group,while the scores of MMSE and ADL were significantly higher than those in routine group(P<0.05).There were ε2,ε3 and ε4 alleles in ApoE,of which ε3 had the highest expression frequency(55 cases),followed by ε4 and ε2.There was no significant difference in detection rate of different ApoE genes among the three groups(P>0.05).The NPI scores of ApoE ε4 patients were significantly higher than those of ApoE ε3 and ApoE ε2 patients(P<0.05).Conclusion Non-drug therapy has a significant effect on senile dementia patients,which can effectively alleviate dementia and BPSD,improve cognitive function and daily living ability.ApoE ε4 gene is closely associated with BPSD in senile dementia patients.