Interferon-Alpha Induced Severe Hypothyroidism Followed by Graves' Disease in a Patient Infected with Hepatitis C Virus
International Journal of Thyroidology
;
: 230-234, 2015.
Article
in English
| WPRIM
| ID: wpr-103829
ABSTRACT
Interferon-alpha (IFN-alpha) is an important therapeutic agent for hepatitis C virus (HCV) infection, but has various side effects including thyroiditis. We report a case of interferon-induced non-autoimmune hypothyroidism followed by autoimmune-medicated Graves' disease. A 59-year-old woman was diagnosed with chronic active hepatitis C; she had been treated with IFN-alpha and ribavirin for 24 weeks. Before starting the IFN-alpha, her thyroid function was normal and she was negative for autoantibodies. Severe hypothyroidism developed 5 weeks after halting the IFN-alpha, with the Graves' disease phase arising at 32 weeks. For accurate diagnosis and appropriate treatment of thyroid dysfunction during treatment with IFN-alpha, we need to understand and consider rare cases of multiphasic disorder involving both non-autoimmune and autoimmune thyroiditis induced by IFN-alpha.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ribavirin
/
Autoantibodies
/
Thyroid Gland
/
Thyroiditis
/
Thyroiditis, Autoimmune
/
Graves Disease
/
Interferons
/
Interferon-alpha
/
Hepatitis C
/
Hepacivirus
Type of study:
Diagnostic study
Limits:
Female
/
Humans
Language:
English
Journal:
International Journal of Thyroidology
Year:
2015
Type:
Article
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