Characteristics of clinical symptoms in multiple system atrophy patients with white matter hyperintensities / 中风与神经疾病杂志

ABSTRACT

@#Objective　To explore the relationship between white matter hyperintensity (WMH) and clinical symptoms in patients with multiple system atrophy (MSA),and the risk factors of WMH in patients with MSA.Methods　A total of 88 patients with MSA were included.The periventricular white matter hyperintensity (PVH) and deep white matter hyperintensity (DWMH) were assessed according to MRI and the Fazekas scale.The patients were divided into three groups according to the severity of PVH or DWMH.The baseline data,motor symptoms,cognitive function,urinary symptoms and constipation were compared among different groups.Logistic regression was used to analyze the risk factors of WMH in patients with MSA.Results　A significant difference was detected in age at admission,age at onset,hypertension,coronary heart disease,UMSARS total score,UMSARS Ⅱ score and UMSARS Ⅳ score between different PVH grades.A significant difference was detected in age at admission,age at onset,hypertension,coronary heart disease,UMSARS total score,UMSARS Ⅰ score,UMSARS Ⅱ score and UMSARSⅣ score between different DWMH grades.Logistic regression analysis showed that age at admission and hypertension were independent risk factors for WMH in patients with MSA.Conclusion　WMH is present in some MSA patients and related to motor symptoms and severity of the disease.Age and hypertension influence the occurrence of WMH.