Neurotrophins and IGFs Attenuated Haloperidol-Induced Neuronal Apoptosis in Mouse Cortical Cell Cultures / 신경정신의학
Journal of Korean Neuropsychiatric Association
;
: 920-927, 2000.
Article
in Korean
| WPRIM
| ID: wpr-103925
ABSTRACT
OBJECTIVES:
We examined the effects of neurotrophins and insulin-like growth factors on cell death induced by haloperidol, a typical anti-psychotic agent.METHOD:
Neocortices from 14- or 15-daysold fetal mice for neuron-glia co-cultures were used for this experiment.RESULT:
Twenty-four hours treatment of mouse cortical cell cultures with 30 M haloperidol-induced wide spread neuronal apoptosis characterized by cell body shrinkage, DNA fragmentation and condensation. Concurrent treatment with growth factors, BDNF, NT4/5, IGF-I and IGF-II, protect the neurons from the haloperidol-induced neuronal apoptosis(HINA) in a dose dependent manner(10-100ng/ml).CONCLUSION:
The present study suggests the possibility that haloperidol toxicity can be hampered with growth factors. Further study about the mechanism underlying the protective capacity of the growth factors on HINA may lead to the development of the new protective strategy for tardive dyskinesia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Somatomedins
/
Insulin-Like Growth Factor I
/
Insulin-Like Growth Factor II
/
Cell Death
/
Apoptosis
/
Coculture Techniques
/
Cell Culture Techniques
/
Brain-Derived Neurotrophic Factor
/
Neocortex
/
Intercellular Signaling Peptides and Proteins
Limits:
Animals
Language:
Korean
Journal:
Journal of Korean Neuropsychiatric Association
Year:
2000
Type:
Article
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