Analysis of prevalence，related factors of orthostatic intolerance in patients with Type 2 diabetes / 中风与神经疾病杂志

ABSTRACT

@#To explore the prevalence and related factors of orthostatic intolerance in patients with Type 2 diabetes. Methods Patients with Type 2 diabetes were enrolled，admitted to the Department of Neurology from September 2020 to October 2021.General clinical data were collected. The active standing TCD test were performed on all the patients，and the changes of blood pressure，heart rate and cerebral hemodynamics were recorded from supine to standing for 1 min，3 min，5 min and 10 min. Orthostatic intolerance questionnaire were completed. Association between Orthostatic intolerance questionnaire score and results of supine to standing TCD test were analyzed. Results A total of 161 patients were enrolled for this study，70 （43.5%） with Symptoms of orthostatic intolerance and 91 （56.5%） without. Correlation analysis showed that Orthostatic intolerance questionnaire score have positive correlation with the magnitude of systolic pressure fall，diastolic pressure fall，Cerebral blood flow velocity fall and cerebral blood flow response to tilt score.（r=0.57、P= 0.000，r=0.44、P=0.000，r=0.30、P=0.022，r=0.24、P=0.044）.Conclusion The proportion of OI in patients with Type 2 diabetes is high，which is associated with orthostatic blood pressure and cerebral blood flow decline.