Study on the correlation between serum 25-hydroxyvitamin D cystatin C and the severity of white matter / 中风与神经疾病杂志

ABSTRACT

@#Objective　To investigate the correlation between serum 25 hydroxyvitamin D ［25 (OH)D］.Cystatin C (Cys-C) and the severity of leukoaraiosis (LA).Methods　One hundred and thirty LA patients admitted to our hospital from February 2018 to February 2020 were divided into mild group (n=43),moderate group (n=45) and severe group (n= 42).In the same period.40 healthy people who had physical examination in our hospital were included as control group.All subjects were tested for serum 25(OH)D and Cys-C levels,and the MoCA score was performed for LA patients.The correlation between serum 25 (OH)D and Cys-C and the correlation between serum 25 (OH)D.Cys-C and MoCA scores were analyzed.ROC was used to analyze the AUC of serum 25 (OH)D and Cys-C to assess LA aggravation.The correlation between serum 25 (OH)D.Cys-C and the severity of La was observed.Results　The serum 25 (OH)D of mild，moderate and severe groups was lower than that of control group and the serum Cys-C of mild，moderate and severe groups was higher than that of control group (P<0.05).Pearson linear analysis showed that serum 25 (OH)D was negatively correlated with Cys-C (r=-0.767) and positively correlated with MOCA score (r=0.588).Serum Cys-C was negatively correlated with MOCA score (r=-0.694)(P<0.05).The AUC of serum 25 (OH)D and Cys-C assessment of LA exacerbation were 0.760 and 0.749，respectively.Logistic regression analysis showed that increased serum Cys-C and decreased serum 25 (OH)D were risk factors for LA exacerbation (P<0.05).Serum 25 (OH)D(r=-0.666) was negatively correlated with the degree of La.While serum Cys-C (r=0.840) was positively correlated with the degree of La (P<0.05).Conclusion　The greater the degree of LA.the lower the patient’s serum 25 (OH)D and the higher the serum Cys-C.The two are closely related to the progression of LA.