Clinical analysis of 26 cases of dementia with Lewy bodies / 中风与神经疾病杂志

ABSTRACT

@#Objective　To investigate the clinical and neuroimaging features of dementia with Lewy bodies (DLB).Methods　The clinical data of 26 patients with DLB were retrospectively analyzed.Results　The initial symptoms were cognitive symptoms (65%),Parkinsonism (19%),or both.In the clinical manifestations,38% of patients showed fluctuating cognition,77% showed Parkinsonism,62% showed hallucinations,and 50% showed rapid eye movement sleep behavior disorder,65% showed severe autonomic dysfunction.59% of the patients revealed the preservation of hippocampal structures on MRI scan.In addition,FDG PET showed hypo-metabolism in bilateral parietal and occipital lobe in 7 patients,and CFT PET demonstrated reduced dopamine transporter uptake in the basal ganglia in 2 patients.Conclusion　Cognitive impairment was the initial symptoms in most patients with DLB,and the clinical symptoms were characterized by Parkinsonism,hallucinations,rapid eye movement sleep behavior disorder and psychiatric symptoms.Neuroimaging examination including MRI and PET scan were useful to diagnose.