Sclerosing Angiomatoid Nodular Transformation (SANT) in Spleen: A Case Report
Korean Journal of Pathology
;
: 111-114, 2011.
Article
in English
| WPRIM
| ID: wpr-104146
ABSTRACT
Sclerosing angiomatoid nodular transformation (SANT) of spleen is a rare inflammatory tumor-like vascular lesion composed of angiomatoid nodules in a fibrosclerotic background. We report herein on a case of SANT in the spleen with its pathologic features, and review the related literature. A 50-year-old woman presented with mild left upper quadrant discomfort and tenderness and she showed a 6 cm-sized solitary splenic mass on computed tomography. She underwent laparoscopic splenectomy. Grossly, the spleen showed a well circumscribed round-shaped solid mass with multinodular hemorrhagic surfaces. Microscopically, the mass consisted of multiple angiomatoid nodules surrounded by collagen bundles with fibroblasts and a lymphoplasma cell infiltration. Immunohistochemically, the cells of the angiomatoid nodules were positive for CD31, CD30, CD34, alpha-smooth muscle actin, and VWF-VIII, but they were negative for CD8, anaplastic lymphoma kinase protein, and D2-40. The patient has been under close follow-up without recurrence.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phosphotransferases
/
Recurrence
/
Spleen
/
Splenectomy
/
Follow-Up Studies
/
Actins
/
Collagen
/
Receptor Protein-Tyrosine Kinases
/
Platelet Endothelial Cell Adhesion Molecule-1
/
Fibroblasts
Type of study:
Observational study
/
Prognostic study
Limits:
Female
/
Humans
Language:
English
Journal:
Korean Journal of Pathology
Year:
2011
Type:
Article
Similar
MEDLINE
...
LILACS
LIS