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Molecular and Treatment Characteristics of SMARCB1 or SMARCA4-Deficient Undifferentiated Tumor: Retrospective Case Series / Journal of the Korean Cancer Association, 대한암학회지
Article in En | WPRIM | ID: wpr-1042356
Responsible library: WPRO
ABSTRACT
SMARCB1 or SMARCA4-deficient sinonasal carcinoma or thoracic undifferentiated tumor has aggressive nature with a poor prognosis. Patients with this disease were diagnosed by immunohistochemistry or next-generation sequencing. Those who were able to receive a surgery tended to be cured, while the others treated with chemotherapy, radiation therapy, or immune checkpoint inhibitor were often insensitive to these therapies. However, one having CD274 (PD-L1) amplification showed the response to immune checkpoint inhibitor and a good prognosis. We believed that this report could provide promising information for determining the optimal treatment option.
Full text: 1 Index: WPRIM Language: En Journal: Cancer Research and Treatment Year: 2024 Type: Article
Full text: 1 Index: WPRIM Language: En Journal: Cancer Research and Treatment Year: 2024 Type: Article