Controls of Nuclear Factor-Kappa B Signaling Activity by 5’-AMP-Activated Protein Kinase Activation With Examples in Human Bladder Cancer Cells / 대한배뇨장애요실금학회지
International Neurourology Journal
;
: 182-187, 2016.
Article
in English
| WPRIM
| ID: wpr-10454
ABSTRACT
Generally, both lipopolysaccharide (LPS)- and hypoxia-induced nuclear factor kappa B (NF-κB) effects are alleviated through differential posttranslational modification of NF-κB phosphorylation after pretreatment with 5'-AMP-activated protein kinase (AMPK) activators such as 5'-aminoimidazole-4-carboxamide ribonucleotide (AICAR) or the hypoglycemic agent metformin. We found that AICAR or metformin acts as a regulator of LPS/NF-κB-or hypoxia/NF-κB-mediated cyclooxygenase induction by an AMPK-dependent mechanism with interactions between p65-NF-κB phosphorylation and acetylation, including in a human bladder cancer cell line (T24). In summary, we highlighted the regulatory interactions of AMPK activity on NF-κB induction, particularly in posttranslational phosphorylation and acetylation of NF-κB under inflammatory conditions or hypoxia environment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phosphorylation
/
Acetylation
/
Protein Kinases
/
Urinary Bladder
/
Urinary Bladder Neoplasms
/
Cell Line
/
Protein Processing, Post-Translational
/
Lipopolysaccharides
/
NF-kappa B
/
Prostaglandin-Endoperoxide Synthases
Limits:
Humans
Language:
English
Journal:
International Neurourology Journal
Year:
2016
Type:
Article
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