Paradoxical Trichomegaly of the Eyelashes During Treatment with EGFR Inhibitors: 2 Case Report
Journal of the Korean Ophthalmological Society
;
: 908-912, 2014.
Article
in Korean
| WPRIM
| ID: wpr-104548
ABSTRACT
PURPOSE:
To introduce 2 cases of trichomegaly associated with the use of systemic epidermal growth factor receptor (EGFR) inhibitors for the treatment of lung cancer. CASESUMMARY:
An 82-year-old female visited our clinic for ocular pain in both eyes. She was suffering from metastatic lung cancer and was under daily treatment with gefitinib (Iressa(R), AstraZeneca, London, UK) for 6 months. On ophthalmologic examination, she presented with abnormally elongated eyelashes, hyperemic conjunctiva and dense corneal erosion. A 52-year-old male who was diagnosed with non-small cell lung cancer 7 months before and treated with erlotinib (Tarceva(R) OSI Pharmaceuticals, Inc., Melville, NY, USA) was referred to our clinic for injection and foreign body sensation in both eyes. Although there were no remarkable changes in eyelashes at the initial visit, long, curly, uneven eyelashes were observed after 3 months.CONCLUSIONS:
Due to the increased use of EGFR inhibitors in anti-cancer treatment, ophthalmologists should be aware of these chemotherapeutics' adverse effects.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sensation
/
Carcinoma, Non-Small-Cell Lung
/
Conjunctiva
/
Eyelashes
/
ErbB Receptors
/
Erlotinib Hydrochloride
/
Foreign Bodies
/
Lung Neoplasms
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
Korean
Journal:
Journal of the Korean Ophthalmological Society
Year:
2014
Type:
Article
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