No Association between DRD2 polymorphism Ser311/Cys311 and Bipolar Disorder in Korean Population / 신경정신의학
Journal of Korean Neuropsychiatric Association
;
: 1488-1493, 1999.
Article
in Korean
| WPRIM
| ID: wpr-104564
ABSTRACT
OBJECTIVES:
This study was designed to investigate the association between Ser311/Cys311 polymorphism in the dopamine D2 receptor gene and bipolar disorder in korean population.METHOD:
Ser311/Cys311 polymorphism in the dopamine D2 receptor gene was typed with PCR in 86 bipolar disorders and 100 normal controls.RESULTS:
Genotype of Ser/Ser, Ser/Cys, Cys/Cys were 82 (95.3%), 4 (4.7%), 0 (0.0%) respectively in the bipolar disorders, 96 (96.0%), 4 (4.0%), 0 (0.0%) respectively in the controls. Allele frequencies of Ser and Cys were 168 (97.7%), 4 (2.3%) in the bipolar disorders, 196 (98.0%), 4 (2.0%) in the controls. There were no differencies in genotype distribution and allele frequencies of dopamine D2 receptor gene polymorphism Ser311/Cys311 between in the bipolar disorders and in the controls.CONCLUSION:
These result suggests dopamine D2 receptor gene polymorphism Ser311/Cys311 is not causally related to the development of bipolar disorder in korean population.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bipolar Disorder
/
Polymerase Chain Reaction
/
Receptors, Dopamine D2
/
Gene Frequency
/
Genotype
Language:
Korean
Journal:
Journal of Korean Neuropsychiatric Association
Year:
1999
Type:
Article
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