Molecular Genetic Study for FMR-1 Gene in Autistic Children / 신경정신의학
Journal of Korean Neuropsychiatric Association
;
: 1479-1487, 1999.
Article
in Korean
| WPRIM
| ID: wpr-104565
ABSTRACT
OBJECTIVES:
To elucidate an association of the fragile X syndrome with autism, Southern blot analysis was performed in 66 autistic children aged from 2 years to 11 years.METHODS:
Subjects were 66 autistic children with of autistic disorder diagnosed by DSM-IV criteria and Childhood Autism Rating Scale-Korean version. Genomic DNA was extracted from peripheral blood and DNA was used to detect a FMR (Fragile Mental Retardation)-1 gene. Xho/PstI probes and two restriction enzymes (EcoRI, EagI)were used for Southern blot analysis.RESULTS:
There were one boy with a methylated mosaic pattern and 3 boys and 2 girls with an unmethylated premutation band. But there was no full mutation pattern.CONCLUSION:
Although the possibility of the relationship between autistic disorder and FMR-1 gene has been suggested, the results from this study do not provide any definite association of FMR-1 gene with autism in autistic children.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Autistic Disorder
/
DNA
/
Blotting, Southern
/
Diagnostic and Statistical Manual of Mental Disorders
/
Fragile X Syndrome
/
Molecular Biology
Limits:
Child
/
Female
/
Humans
/
Male
Language:
Korean
Journal:
Journal of Korean Neuropsychiatric Association
Year:
1999
Type:
Article
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