Effect of Clozapine on the Quality of Life in Treatment-Resistant Schizophrenic Patients / 신경정신의학
Journal of Korean Neuropsychiatric Association
;
: 1447-1458, 1999.
Article
in Korean
| WPRIM
| ID: wpr-104568
ABSTRACT
OBJECTIVES:
This prospective study was performed to determine effects of clozapine treatment on the quality of life of treatment-resistant schizophrenic patients.METHOD:
Subjects were 18 patients with treatment-resistant schizophrenia. Patient's PANSS, BPRS and Simpson-Angus Rating Scale was assessed at 9 time points baseline, the 2th, 4th, 6th, 8th, 10th, 12th, 16th, and 20th weeks of treatment. We chose to use the Quality of Life Scale (QLS) developed by Heinrichs and associates to evaluate the effect on the quality of life. The QLS was scaled at every month of treatment.RESULTS:
Eighteen of twenty-three patients completed the five months trial of clozapine. Three PANSS factors (positive, negative, general) and BPRS total scores showed a significant improvement at the fifth month of clozapine treatment. The adverse effects of clozapine did not show a significant improvement. After five months of clozapine treatment, there were an increase of 52.69% in the total QLS score and a significant improvement of two QLS factors (interpersonal relations, intrapsychic foundation). Particularly two PANSS factors(negative, general) had a significant correlation with the QLS score.CONCLUSIONS:
This study suggests that clozapine treatment has a positive effect on quality of life of treatment-resistant schizophrenic patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Quality of Life
/
Schizophrenia
/
Prospective Studies
/
Clozapine
Type of study:
Observational study
/
Risk factors
Limits:
Humans
Language:
Korean
Journal:
Journal of Korean Neuropsychiatric Association
Year:
1999
Type:
Article
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